Who saw this coming? Not I:
A new study finds that carvedilol, a drug typically used to treat high blood pressure, can protect against the sun-induced cell damage that leads to skin cancer. Researchers serendipitously discovered the beta blocker’s cancer-fighting properties after making an error in the lab.
Sherry Liang, a graduate student at the Western University of Health Sciences College of Pharmacy, will present the new findings at the American Society for Pharmacology and Experimental Therapeutics annual meeting during the Experimental Biology 2017 meeting, to be held April 22-26 in Chicago.
“What began as an experimental error led to a very interesting scientific discovery,” said Ying Huang, PhD, coleader of the research team with Bradley T. Andresen, PhD. “Our research could lead to the development of a class of new cancer-preventive agents.”
Carvedilol’s cancer-fighting properties were discovered when a former graduate student in Huang’s lab was studying whether carvedilol and similar beta blockers might increase cancer risk. The student inadvertently tested carvedilol’s anticancer effect rather than its ability to promote cancer, finding that carvedilol surprisingly showed some protective effects against skin cancer.
Which is pure serendipity, given the drug’s primary function, warding off congestive heart failure.
Better yet, carvedilol — always trust drugs that end with “lol” — is out of patent and now swims with the $4 generics. (Former trade name: “Coreg.”)
Sarah Sloan MacLeod’s first claim to fame, five years ago, was a YouTube complaint about slut-shaming. She was 13 or so at the time.
I’ve continued to follow her, because she’s never, ever done anything uninteresting, at least in my semi-humble opinion. And this threw me, just because I didn’t expect it:
She usually puts out new videos on her YouTube channel on Wednesdays.
I’m sure it’s possible to make a film worse than this, but I don’t even want to imagine it:
How bad is it? This bad:
Apparently, the film is so awful that Paramount Pictures has delayed its release three times and taken the odd step of booking a $115 million impairment charge, Automotive News reports. A write-down, in other words.
According to Wikipedia, the budget was $125 million. It would have been easier to get several stacks of $100 bills and set them on fire.
I knew things had gotten weird when the local Triple-A ball club finished off a road trip with a 7-1 win — in ten innings. “Where was all this offense earlier?”
And then they promptly came home and lost one.
I’ve had downtime out the wazoo.
Please help if you can.
An end-of-the-world — well, end-of-your-world, anyway — short story by Selena Larson.
I am here for your story. You died without one, though your voice may have gone silent long before your heart did. Valuable data is distributed among the blurry photos and status updates you left behind. It is my duty to purge it.
I feel for the poor soul who has to wade through my 31 years (so far) of online archives. My browser history alone will be daunting.
If I ever ask myself “Self, what would happen if you plunged Florence Welch into Carnival of Souls?” I’ll have this answer waiting for me:
Song: wonderful. Video ambiance: more than a little disturbing.